CHANGES OF FUNCTIONAL AND BIOCHEMICAL BLOOD PARAMETERS IN WISTAR RATS AND IN SPONTANEOUSLY HYPERTENSIVE RATS OF THE SHR LINE DURING SHORTTERM AND LONG TREDMILL RUNNING.

CHANGES OF FUNCTIONAL AND BIOCHEMICAL BLOOD PARAMETERS IN WISTAR RATS AND IN SPONTANEOUSLY HYPERTENSIVE RATS OF THE SHR LINE DURING SHORTTERM AND LONG TREDMILL RUNNING.

MD Professor, Academician Arman. Lawson. Cardiologist, PhD in Medicine, D.Sc in Neurosciences.

 Pediatric State Medical Academy, Russian Federation Ministry of Health, St. Petersburg, Russia -(Departement of cardiology).2003

Professor. PhD, D.Sc M. N. Maslova

 Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia 2003

Abstract—Effects were studied of single (40 min) or repeated exercise load (tredmill running, 14 m/min, 30 min) on the physiological and biochemical blood parameters characterizing the organism energetic and metabolic processes in complex experiments on male Wistar rats, on spontaneously hypertensive rats of the SHR line, and their normotensive control WKY. The mixed blood was used for determination of hematocrit, red Bloom cell count, hemoglobin concentration, level of 2,3 diphosphoglycerate (2,3DPG) in red blood cells, erythrocyte acetylcholinesterase (AChE) activity, glucose, cholesterol, and triglyceride concentration, as well as plasma corticosterone level. To assess the erythrocyte population characteristics, the acidity erythrogram was determined. The weights of adrenal glands and spleen were evaluated. The single running induced a typical stress response. After the repeated exercise load (the 7–14 day running), Wistar and WKY rats were well adopted to the load, unlike the SHR line rats that were practically not adapted to the repeated tredmill running.

 

Leave a Reply